The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

TMEM18 is a regulator of adipogenesis and involved in PPARG signalling in vivo

s of the 51st Workshop for Pediatric Research 51st Workshop for Pediatric Research Göttingen, Germany

متن کامل

Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.

In addition to their role in cell cycle progression, new data reveal an emerging role of D-type cyclins in transcriptional regulation and cellular differentiation processes. Using 3T3-L1 cell lines to study adipogenesis, we observed an up-regulation of cyclin D3 expression throughout the differentiation process. Surprisingly, cyclin D3 was only minimally expressed during the initial stages of a...

متن کامل

FABP4 Attenuates PPARg and Adipogenesis and Is Inversely Correlated With PPARg in Adipose Tissues

Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Here we demonstrate that FABP4 triggers the ubiquitination and subsequent proteasomal degradation of peroxisome proliferator–activated receptor g (PPARg), a master regulator ...

متن کامل

Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1 and Gli2 mRNA and Shh protein

Objective: Although azelaic acid is effective for treatment of acne and rosacea, the biological activity of azelaic acid and the effect of its combination therapy with minoxidil were not elucidated with regard to hair growth. Materials and Methods: In this study, mouse vibrissae follicles were dissected on day 10 after depilation. Then, the bulb and bulge...

متن کامل

Obesity Risk Gene TMEM18 Encodes a Sequence-Specific DNA-Binding Protein

Transmembrane protein 18 (TMEM18) has previously been connected to cell migration and obesity. However, the molecular function of the protein has not yet been described. Here we show that TMEM18 localises to the nuclear membrane and binds to DNA in a sequence-specific manner. The protein binds DNA with its positively charged C-terminus that contains also a nuclear localisation signal. Increase ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Cell Reports

سال: 2020

ISSN: 2211-1247

DOI: 10.1016/j.celrep.2020.108295